Cotrimoxazole

Content
per tab : Trimetroprim 80mg and Sulfamethoxazole 400mg.
Forte caplet: Trimetoprim 160mg and Sulfamethoxazole 800mg
Syrup: Per 5 mL syr Trimetoprim 40mg and Sulfamethoxazole 200mg

Indication:
Gastro Intestinal Tract, respiratorius tract, skin and other infections caused by sensitive microorganisms.

Dosis:
Adult 2 tab, Children 5 – 12 years 1 tablet/ syrup 2 tsp, Children 6 month – 5 years 1 tsp, children 2 month – 6 month ½ tsp. to be taken 2 times daily.
Severe infection: dosis may be increased.

Contra Indication:
Severly impaired hepatic or renal function. Hypersensitivity to sulfonamides, blood dyscrasias, Pregnancy and lactation. Infant < 2 month. Porphyria.

Special Precaution:
Folic Acid and G6PD deficiency. Poor nutritional status. Elderly and patients with reduced kidney function.
Adverse Reactions:
Gastro Intestinal Disturbances, Stevens-Johnson & Lyell’s syndrome, Rarely, hepatitis, blood disorders, pseudomembranous colitis.

Drug Interaction:
Effects reduced by PABA and procaine-type local anesth and enhanced by highly bound drugs. May potenciate effects of methotrexate, warfarin, sulfonylureas.